July 4, 2022

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You are Your Only Limit

MAIA Biotechnology, Inc. Establishes Wholly Owned Subsidiaries in Romania and Australia to Assistance World Progress of THIO

5 min read

-Expanded clinical progress presence is expected to accelerate things to do for THIO-101 Stage 2 Demo for NSCLC-

CHICAGO–(Organization WIRE)– MAIA Biotechnology, Inc., a targeted treatment, immuno-oncology corporation concentrated on building possible first-in-course oncology medicine (“MAIA”), announced right now that the firm has set up two wholly-owned subsidiaries in Romania and Australia to broaden and speed up its worldwide development plan for THIO, a telomere-concentrating on agent currently in improvement to assess its exercise in several cancer indications.

“We are pleased to grow our clinical progress operations across 3 continents, which reinforces MAIA’s determination to providing our novel therapeutic THIO to cancer individuals throughout the globe,” mentioned Vlad Vitoc, M.D., MAIA’s Chairman and Main Executive Officer. “Currently, our attempts are concentrated on website initiation and affected person enrollment throughout Jap Europe and Australia.”

The Romanian subsidiary, MAIA Biotechnology Romania S.R.L., and the Australian subsidiary, MAIA Biotechnology Australia, will be employed to perform a variety of actions which includes internet site initiation and individual enrollment, relevant to THIO-101, a Phase 2 medical research assessing the administration of THIO followed by cemiplimab in patients with highly developed Non-Compact Mobile Lung Cancer (NSCLC). The principal objectives of the trial are to appraise the safety of THIO administered as a immediate anticancer and priming immune process agent prior to cemiplimab administration and to evaluate the scientific efficacy of THIO in sufferers.

“In Europe, we have recognized 22 clinical demo web sites throughout 5 countries. In Australia, we have 3 medical trial internet sites, with additional coming on-line shortly. We are very pleased with this development,” claimed Mihail Obrocea, MD, Chief Healthcare Officer of MAIA.

Joseph F. McGuire, MAIA’s Chief Financial Officer, additional, “The institution of our subsidiaries in Europe and Australia is a significant action in the world wide enlargement of our business.”

About THIO-101, a Stage 2 Scientific Trial

This trial (THIO-101) will be the 1st to take a look at THIO’s probable immune method activation outcomes in NSCLC clients by administering THIO in progress of administration of the checkpoint inhibitor cemiplimab (co-produced by Regeneron and Sanofi), perhaps letting for immune activation and PD-1 sensitivity to acquire result. The demo will test the speculation that small doses of THIO administered prior to checkpoint inhibitor cure will reverse resistance and extend immune response in sufferers with highly developed NSCLC who beforehand did not answer or progressed soon after to start with-line treatment regimen made up of a checkpoint inhibitor. The demo design has two primary objectives: (1) to examine the security of THIO administered as an anticancer agent and a priming immune technique agent prior to cemiplimab administration and (2) to assess the clinical efficacy of THIO adopted by cemiplimab working with Over-all Response Amount (ORR) as the principal scientific endpoint. We assume the review to start out at first in Australia and Europe followed by the United States. The business has received Ethics Committee approval to move forward with the THIO-101 demo in Australia.

About THIO

THIO (6-thio-dG or 6-thio-2’-deoxyguanosine) is a telomere-targeting agent currently in scientific development to consider its exercise in non-smaller cell lung cancer (NSCLC). Telomeres, together with the enzyme telomerase, enjoy a basic job in the survival of cancer cells and their resistance to present-day therapies. THIO is staying produced for patients with NSCLC that have progressed over and above the common-of-care routine of current checkpoint inhibitors.

About MAIA Biotechnology, Inc.

MAIA is a qualified therapy, immuno-oncology organization centered on the improvement and commercialization of likely 1st-in-course drugs with novel mechanisms of action that are intended to meaningfully make improvements to and increase the lives of men and women with cancer. Our lead software is THIO, a opportunity initially-in-course cancer telomere concentrating on agent in medical improvement for the procedure of individuals with telomerase-constructive cancers. For far more facts, be sure to visit www.maiabiotech.com.

Forward Seeking Statements

MAIA cautions that all statements, other than statements of historic facts, contained in this press launch, are ahead-on the lookout statements. Ahead-searching statements are topic to identified and not known risks, uncertainties, and other components that could bring about our or our industry’s actual benefits, levels or activity, functionality or achievements to be materially unique from individuals anticipated by such statements. The use of words and phrases such as “may,” “might,” “will,” “should,” “could,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “project,” “intend,” “future,” “potential,” or “continue,” and other similar expressions are supposed to detect ahead on the lookout statements. However, the absence of these words and phrases does not suggest that statements are not ahead-seeking. For instance, all statements we make about (i) the initiation, timing, price, progress and final results of our preclinical and scientific reports and our investigate and advancement courses, (ii) our skill to progress products candidates into, and successfully total, clinical scientific tests, (iii) the timing or likelihood of regulatory filings and approvals, (iv) our skill to acquire, manufacture and commercialize our merchandise candidates and to make improvements to the producing approach, (v) the price and diploma of market acceptance of our item candidates, (vi) the sizing and development opportunity of the marketplaces for our solution candidates and our skill to provide all those markets, and (vii) our expectations concerning our skill to get and retain mental property safety for our merchandise candidates, are ahead hunting. All forward-seeking statements are based on recent estimates, assumptions and anticipations by our administration that, although we believe that to be reasonable, are inherently uncertain. Any ahead-hunting statement expressing an expectation or perception as to long run functions is expressed in great religion and considered to be sensible at the time this sort of ahead-on the lookout statement is produced. Even so, these statements are not ensures of foreseeable future activities and are subject matter to dangers and uncertainties and other things past our manage that may well trigger real outcomes to differ materially from individuals expressed in any ahead-searching statement. Any ahead-on the lookout statement speaks only as of the day on which it was built. We undertake no obligation to publicly update or revise any forward-on the lookout statement, irrespective of whether as a outcome of new data, potential situations or or else, except as required by law. In this release, unless the context necessitates or else, “MAIA,” “Company,” “we,” “our,” and “us” refers to MAIA Biotechnology, Inc. and its subsidiaries.

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