June 21, 2024


You are Your Only Limit

Vir Biotechnology Announces Various Abstracts Highlighting

7 min read

SAN FRANCISCO, June 07, 2023 (Globe NEWSWIRE) — Vir Biotechnology, Inc. (Nasdaq: VIR) today declared that 5 abstracts highlighting new facts from the Company’s wide hepatitis portfolio addressing both of those hepatitis B virus (HBV) and hepatitis D virus (HDV) have been recognized for presentation at the annual meeting of the European Association for the Analyze of the Liver, EASL Congress 2023, getting place in Vienna from June 21-24.

“The accepted abstracts underscore the development Vir is generating with our sturdy hepatitis B and D portfolio and the prospective impact the combination of VIR-3434 and VIR-2218 could have on both of those viruses,” said Phil Pang, M.D., Ph.D., Vir’s Govt Vice President, Chief Clinical Officer and Interim Head of Research. “We look ahead to sharing new details from our scientific progress applications that give us self-confidence in our solution toward a functional overcome for HBV and a therapy for the lengthy-time period suppression of HDV.”

The late-breaker oral presentation, which was accepted as the only HBV-targeted late-breaker abstract, will offer new data relevant to the safety and efficacy of VIR-2218 with or without the need of pegylated interferon alfa (PEG-IFN-α) in virally-suppressed individuals with continual HBV infection.

A next oral presentation will share adhere to-up info from Component A of the Phase 2 MARCH trial. At first offered at the American Affiliation for the Study of Liver Disorders (AASLD) The Liver Meeting® in November 2022, Part A was intended to, and correctly shown, the on-procedure additivity of VIR-2218 and VIR-3434. Importantly, these quick-length Element A cohorts, in which these investigational treatments ended up co-administered for only 4 or 12 weeks, knowledgeable the protocol for Part B, which is designed to evaluate whether VIR-3434 and VIR-2218, specified with or without the need of PEG-IFN-α for 24 and 48 weeks, can end result in a purposeful cure for long-term HBV. Original on-therapy info from the 24-week cohorts are expected in the 2nd fifty percent of 2023.

Finally, a few poster shows will focus on the prospective efficacy of VIR-2218 and VIR-3434 in preclinical types of HDV, the pharmacokinetics of HBV monotherapy with VIR-3434, and the eligibility and initiation of HBV treatment method in a real-planet placing.

Presentation particulars are as follows:

Late-Breaker Oral Presentation

  • Title: Protection and efficacy of VIR-2218 with or devoid of pegylated interferon alfa in virally-suppressed individuals with continual hepatitis B virus infection: write-up-therapy stick to-up (Oral Presentation #LBO-02)
    Session: Late-Breaker Session
    Date: Saturday, June 24
    Time: 11:15-11:30 CEST (5:15-5:30 a.m. EDT)
    Presenter: Prof. Gentleman-Fung Yuen, M.D., Ph.D., D.Sc., Professor of Medicine, Queen Mary Hospital, Faculty of Clinical Medication Condition Crucial Laboratory of Liver Investigate, The University of Hong Kong

Oral Presentation

  • Title: Safety and antiviral action of small-duration combinations of the investigational little interfering ribonucleic acid (siRNA) VIR-2218 with the neutralizing, vaccinal monoclonal antibody VIR-3434: publish-treatment stick to-up from the Period 2 MARCH trial (Abstract #1273 Oral Presentation #OS-031)
    Session: Viral hepatitis B/D – New therapies
    Date: Thursday, June 22
    Time: 17:30-17:45 CEST (11:30-11:45 a.m. EDT)
    Presenter: Prof. Edward Gane, M.D., Professor of Medication at the College of Auckland, New Zealand, and Main Hepatologist, Transplant Physician and Deputy Director of the New Zealand Liver Transplant Unit at Auckland Metropolis Hospital

Poster Presentations

  • Title: VIR-2218 and VIR-3434 remedy is efficacious in preclinical types of hepatitis delta virus infection (Summary #1333 Poster #Top-109)
    Session: Viral hepatitis B and D: New therapies, unapproved therapies or strategies
    Date: Saturday, June 24
    Time: Out there from 9:00 CEST (from 3:00 a.m. EDT)
    Presenter: Florian Lempp, Ph.D., Director, Virology, Vir Biotechnology
  • Title: Solitary dose pharmacokinetics of VIR-3434, a novel neutralizing monoclonal antibody, in contributors with persistent hepatitis B virus infection (Abstract #1305 Poster #SAT-177)
    Session: Viral hepatitis B and D: New therapies, unapproved therapies or tactics
    Day: Saturday, June 24
    Time: Obtainable from 9:00 CEST (from 3:00 a.m. EDT)
    Presenter: Sneha V. Gupta, Ph.D., Director, Clinical Pharmacology, Vir Biotechnology
  • Title: Treatment eligibility and initiation between serious hepatitis B individuals in a authentic-environment placing in the United States (Summary #2613 Poster #WED-141)
    Session: Viral hepatitis B and D: Clinical elements
    Date: Wednesday, June 21
    Time: Readily available from 9:00 CEST (from 3:00 a.m. EDT)
    Presenter: Mark A. Schmidt, Ph.D., M.P.H., infectious sickness epidemiologist, Kaiser Permanente Center for Well being Investigation

The EASL presentation abstracts can be accessed below Situations & Displays in the Traders area of the Vir web page below.

About Continual Hepatitis B
Continual hepatitis B virus (HBV) infection stays an urgent international public wellbeing problem connected with significant morbidity and mortality. About 300 million persons close to the entire world are living with HBV, and approximately 900,000 of them die from associated troubles just about every calendar year. These individuals are substantially underserved by existing therapies with lower useful heal prices, lifelong day-to-day remedy and/or inadequate tolerability. Vir is operating to reach a functional treatment for the hundreds of thousands of people today with HBV all around the globe as a result of its broad and differentiated portfolio.

About Chronic Hepatitis D
Chronic hepatitis D virus (HDV) an infection occurs as a simultaneous co-infection or tremendous-infection with hepatitis B virus (HBV). An estimated 12 million folks globally are contaminated with HDV, symbolizing around 5% of all those contaminated with HBV. HDV-HBV co-an infection is viewed as the most critical form of continual viral hepatitis due to additional speedy development toward hepatocellular carcinoma and liver-associated demise.

About VIR-2218
VIR-2218 is an investigational subcutaneously administered HBV-concentrating on siRNA that Vir believes has the potential to encourage an effective immune reaction and have immediate antiviral action towards HBV and HDV. It is the first siRNA in the clinic to include Increased Stabilization Chemistry Plus (ESC+) engineering to improve balance and lessen off-goal activity, which probably could result in an improved therapeutic index. VIR-2218 is the very first asset in the Company’s collaboration with Alnylam Prescription drugs, Inc. to enter clinical trials.

About VIR-3434
VIR-3434 is an investigational subcutaneously administered antibody created to block entry of hepatitis B and hepatitis D viruses into hepatocytes and to cut down the stage of virions and subviral particles in the blood. VIR-3434, which incorporates Xencor’s Xtend™ and other Fc technologies, has been engineered to likely function as a T cell vaccine versus HBV and HDV, as very well as to have an extended fifty percent-lifestyle.

About Vir Biotechnology
Vir Biotechnology is a business-stage immunology enterprise targeted on combining immunologic insights with reducing-edge technologies to deal with and protect against severe infectious health conditions. Vir has assembled 4 technology platforms that are built to promote and greatly enhance the immune system by exploiting critical observations of pure immune procedures. Its current development pipeline is composed of solution candidates targeting COVID-19, hepatitis B and D viruses, influenza A and human immunodeficiency virus. Vir routinely posts facts that may possibly be crucial to traders on its website.

Forward-Hunting Statements
This push launch consists of ahead-seeking statements inside the which means of the Private Securities Litigation Reform Act of 1995. Terms these as “may,” “will,” “plan,” “potential,” “aim,” “expect,” “anticipate,” “promising” and related expressions (as effectively as other phrases or expressions referencing future events, situations or situations) are supposed to identify forward-seeking statements. These ahead-on the lookout statements are centered on Vir’s anticipations and assumptions as of the date of this press release. Ahead-wanting statements contained in this press launch involve, but are not minimal to, statements about Vir’s strategy and programs the probable medical effects, preliminary facts and the opportunity added benefits, security and efficacy of VIR-2218, VIR-3434, VIR-2218 in blend with VIR-3434 and VIR-2218 and VIR-3434 in mix with PEG-IFNα the original final results of the MARCH scientific trial assessing the blend of VIR-2218 and VIR-3434 Vir’s anticipations relevant to the likely good results of its recent and potential medical advancement plans for HBV and HDV Vir’s strategies and anticipations for its HBV portfolio and hazards and uncertainties related with drug progress and commercialization. A lot of important variables may well result in differences concerning latest expectations and true outcomes, such as the MARCH trial or in knowledge readouts the incidence of adverse protection gatherings threats of unforeseen expenditures, delays or other unexpected hurdles complications in collaborating with other companies profitable development and/or commercialization of choice product or service candidates by Vir’s rivals changes in envisioned or present opposition delays in or disruptions to Vir’s small business or clinical trials because of to the COVID-19 pandemic, geopolitical modifications or other exterior things and surprising litigation or other disputes. Drug growth and commercialization require a superior diploma of threat, and only a small number of research and enhancement plans outcome in commercialization of a product or service. Success in early-stage clinical trials may not be indicative of complete results or outcomes from later on-stage or more substantial-scale medical trials and do not assure regulatory acceptance. You should not area undue reliance on these statements or the scientific info introduced. Other things that might lead to real final results to differ from those people expressed or implied in the forward-on the lookout statements in this push launch are reviewed in Vir’s filings with the U.S. Securities and Trade Fee, including the part titled “Risk Factors” contained therein. Except as required by legislation, Vir assumes no obligation to update any forward-searching statements contained herein to reflect any improve in anticipations, even as new details gets to be available.

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